Objective To search,evaluate and integrate the relevant evidence on the prevention and management of port-related venous thromboembolism（VTE） in cancer patients,and to provide references for clinical practice. Methods We searched CNKI,the BMJ Best Practice,UpToDate,Cochrane Library,JBI Database,CINAHL,Embase,PubMed,China Guideline Clearinghouse（CGC）,Scottish Interhospital Guidelines Network（SIGN）,National Guideline Clearinghouse（NGC）,American Intravenous Nurses Society（INS）,National Comprehensive Cancer Network（NCCN）,American Society of Clinical Oncology（ASCO）,European Society for Medical Oncology（ESMO）,and Registered Nurses’ Association of Ontario （RNAO） for relevant guidelines,systematic reviews,evidence summaries,recommended practices,and expert consensuses. The retrieval period is from the inception of databases to March 10,2021. Results A total of 12 articles were enrolled,including 4 clinical practice guidelines,5 systematic reviews,1 evidence summary and 2 expert consensuses. Totally 30 pieces of best evidence were summarized from 6 aspects,namely VTE risk assessment,catheter placement and maintenance,screening and diagnosis,prevention,management and treatment and health education. Conclusion This study summarized the best evidence on the prevention and management of port-related VTE in cancer patients. Nurses and nursing managers can select and apply the evidence according to clinical situation and patients’ wishes,so as to form a scientific,evidence-based,cancer port-related VTE prevention and management scheme,and improve nursing quality.